A scaleable formal total synthesis of dehydrogliotoxin

作者：McMahon Travis C; Stanley Sarah; Kazyanskaya Edward; Hung Deborah; Wood John L^*

来源：Tetrahedron Letters, 2011, 52(17): 2262-2264.

DOI：10.1016/j.tetlet.2011.01.138

• Gliotoxin
• Dehydrogliotoxin
• Diketopiperazine
• Formal synthesis

A formal total synthesis of the epidithiodiketopiperazine natural product, dehydrogliotoxin (2), utilizing an intramolecular ring closure to form key intermediate 5 is described.

• 出版日期2011-4-27