Association between Carotid Intima-Media Thickness and Cognitive Impairment in a Chinese Stroke Population: A Cross-sectional Study

作者：Yue, Wei; Wang, Anxin; Liang, Hui; Hu, Fengyun; Zhang, Yunshu; Deng, Meiying; Li, Tong; Hu, Xiao; Ye, Zhenxuan; Shen, Ying^*; Ji, Yong^*

来源：Scientific Reports, 2016, 6(1): 19556.

DOI：10.1038/srep19556

• MIDDLE-AGED ADULTS
• ALZHEIMERS-DISEASE
• RISK-FACTORS
• ATHEROSCLEROSIS
• PERFORMANCE
• DEMENTIA
• STENOSIS
• DECLINE
• PREVALENCE

This study aimed to investigate the potential associations between carotid intima-media thickness and cognitive impairment among patients with acute ischemic stroke and to identify the clinical implications. We measured carotid intima-media thickness (IMT) and performed the Mini-Mental State Examination (MMSE) upon the admission of 1,826 acute ischemic stroke patients. The association between IMT and cognitive impairment evaluated by the MMSE was assessed with a multivariate regression analysis. Other clinical variables of interest were also assessed. After adjusting for potential confounders, participants in the highest IMT quartile had a higher likelihood of having cognitive impairments compared with the lowest IMT quartile (odds ratio: 3.01, 95% confidence interval: 2.07-4.37, p < 0.001). Stratified analyses indicated that this positive correlation was similar for the maxIMT and mean IMT of carotid artery measurements. A positive correlation was found between IMT and cognitive impairment in participants with acute ischemic stroke.

• 出版日期2016-1-25
• 单位浙江大学; 首都医科大学; 西安交通大学; 新乡医学院; 贵州省人民医院; 山西医科大学; 天津市环湖医院