科研之友
微信
新浪微博
Facebook
分享链接
摘要
By using dielectric spectroscopy we analyzed the relation between molecular mobility and tendency of the amorphous celecoxib to recrystallize. We found that celecoxib is kinetically a fragile glassformer, contrary to the conclusion reached by others from thermodynamic fragility. The possible correlation of the large tendency of celecoxib to crystallize with various molecular motions have been investigated. Our study shows that the structural relaxation seems to be responsible for devitrification of celecoxib if stored at room temperature similar to 293 K. Notwithstanding, the crystallization can be considered to ultimately be affected by the beta-process (JG-relaxation) because it is the precursor of the structural alpha-relaxation.
- 出版日期2010-10-14
