Adipose-derived stem cells decrease cardiomyocyte damage induced by porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and MAPK markers

作者：Chen Tung Sheng; Kuo Chia Hua; Battsengel Sarnai; Pan Lung Fa; Day Cecilia Hsuan; Shen Chia Yao; Chung Li Chin; Padma V Vijaya; Yao Chen Kai; Lin Yueh Min; Huang Chih Yang^*

来源：Environmental Toxicology, 2018, 33(4): 508-513.

DOI：10.1002/tox.22536

• cardiomyopathy
• endotoxin
• IGF1
• periodontal disease
• stem cell

Heart failure is one of the complications related to periodontal disease. In addition to drugs or herbal medicines, stem cell therapy shows potential in the treatment of cardiomyopathy. This study investigates if stem cells exhibit beneficial effects on cardiomyocyte damage induced by porphyromonas gingivalis endotoxin (Pg-LPS). From the experimental results we find that Pg-LPS reduce cardiomyocyte viability via the activation of apoptosis, hypertrophy, fibrosis and MAPK signaling. Pg-LPS damaged cardiomyocytes co-cultured with adipose-derived stem cells (ADSC) increases cardiomyocyte viability through suppressing the pathological markers described above. Further evidence implies that survival marker, IGF1, secreted from ADSC, may play an important role in the Pg-LPS induced protective effect on cardiomyocyte damage.

• 出版日期2018-4
• 单位中国医科大学