Acute and Long-Term Hemodynamic Effects of Sesame Oil Consumption in Hypertensive Men

作者：Karatzi Kalliopi; Stamatelopoulos Kimon; Lykka Marita; Mantzouratou Pigi; Skalidi Sofia; Manios Efstathios; Georgiopoulos George; Zakopoulos Nikolaos; Papamichael Christos; Sidossis Labros S^*

来源：Journal of Clinical Hypertension, 2012, 14(9): 630-636.

DOI：10.1111/j.1751-7176.2012.00649.x

J Clin Hypertens (Greenwich). 2012; 14:630636. (c) 2012 Wiley Periodicals, Inc. The possible effects of sesame oil on hemodynamics are unknown. The aim of the study was to investigate the acute and long-term effects of sesame oil on hemodynamic responses in hypertensive men. The authors enrolled 30 hypertensive men in a two-phase study. In the first phase, patients consumed 35 g of either sesame oil or control oil. Central and peripheral blood pressure, pulse wave velocity, augmentation index (AI), C-reactive protein, tumor necrosis factor a, malonydealdehyde, and total antioxidant capacity (TAC) were assessed at fast and 2 hours postprandially. In the second phase, patients consumed 35 g of either sesame oil or control oil daily for 2 months. The above-mentioned parameters were assessed before and following 15, 30, and 60 days of oil consumption. Sesame oil decreased central and peripheral diastolic pressures 1 hour postprandially (P=.006). Fifteen days of sesame oil intake decreased peripheral systolic blood pressure (P=.016) and heart ratecorrected AI75 (P=.017) and increased TAC (P=.007). This is the first study to demonstrate a favorable acute and long-term effect of sesame oil on hemodynamics in hypertensive men. Further research is warranted to establish the potential protective role of sesame oil.

• 出版日期2012-9