Asymmetric Carbonyl Migration of alpha-Amino Acid Derivatives via Memory of Chirality

作者：Teraoka Fumiteru; Fuji Kaoru; Ozturk Orhan; Yoshimura Tomoyuki; Kawabata Takeo^*

来源：Synlett, 2011, (4): 543-546.

DOI：10.1055/s-0030-1259324

• amino acids
• chirality
• stereoselectivity
• tetrasubstituted carbon
• carbonyl migration

N-tert-Butoxycarbonylcarbamates of a-amino acid derivatives underwent asymmetric carbonyl migration by treatment with KHMDS in DMF to give a-amino acid derivatives with an additional ester group at the newly formed tetrasubstituted carbon center in up to 99% ee.

• 出版日期2011-3