摘要
This study focuses on analyzing the effects of several factors on the rate of decay of inherent viscosity (iv) during hydrolytic degradation. The analysis was made for oriented PLLA, 96L/4D PLA and 80L/20D,L PLA. The analyzed polymers were found to have identical rate of iv loss (P %26lt; 0.05), given that the materials have otherwise similar initial material properties. The effect of the post-processing residual monomer was dose dependent, i.e. the higher the monomer content the faster the degradation (P %26lt; 0.05). Samples with a smaller diameter (1.1 mm) were found to have a faster rate of iv loss than the samples with a larger diameter (4 mm) (P %26lt; 0.05). A multiple linear regression analysis was used to create a five-component linear model to predict changes in the materials%26apos; inherent viscosity. This model yielded accurate predictions during the initial stages of the hydrolytic degradation process where the iv loss was virtually linear.
- 出版日期2013-5