科研之友
微信
新浪微博
Facebook
分享链接
摘要
Cytochrome bc(1) is a validated drug target of Plasmodium falciparum, the parasite that causes the most lethal form of malaria. The inhibition of cytochrome bc(1) leads to the shutdown of the mitochondrial metabolism and the consequent arrest of pyrimidine biosynthesis essential for parasite development. Aiming to rationalize the stereoelectronic properties and extend the knowledge on a novel series of 4-pyridonimines guiding the search of antimalarial drugs, we carried out an extensive DFT comparative characterization. Results show electronic similarity with clopidol, a known bc(1) complex inhibitor containing the 4(1H)-pyridone scaffold.
- 出版日期2011-5
