A biomimetic approach to the synthesis of a mycolic acid motif

作者：Driver Cathryn H S; Balogun Mohammed O; Toschi Gianna; Verschoor Jan A; Baird Mark S; Pilcher Lynne A^*

来源：Tetrahedron Letters, 2010, 51(8): 1185-1186.

DOI：10.1016/j.tetlet.2009.12.105

• Tuberculosis
• Mycolic acid
• Mycolic acid motif
• Asymmetric anti-aldol reaction

A new method for the stereoselective synthesis of the (R,R)-beta-hydroxy-alpha-alkyl fatty acid fragment of mycolic acids, via an asymmetric anti-aldol reaction is reported. The 'mycolic acid motif' fragment was prepared in three steps and >98% ee.

• 出版日期2010-2-24