Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases

作者：Zhou, Zejun; Ding, Miao; Huang, Lei; Gilkeson, Gary; Lang, Ren^*; Jiang, Wei^*

来源：Clinical Immunology, 2016, 173: 81-86.

DOI：10.1016/j.clim.2016.09.005

• Macrophages
• Monocytes
• Autoimmune disease
• Intestine

Monocytes are precursors of macrophages and key players during inflammation and pathogen challenge in the periphery, whereas intestinal resident macrophages act as innate effector cells to engulf and clear bacteria, secrete cytokines, and maintain intestinal immunity and homeostasis. However, perturbation of toll-like receptor signaling pathway in intestinal macrophages has been associated with tolerance breakdown in autoimmune diseases. In the present review, we have summarized and discussed the role of toll-like receptor signals in human intestinal macrophages, and the role of human intestinal macrophages in keeping human intestinal immunity, homeostasis, and autoimmune diseases.

• 出版日期2016-12
• 单位中国人民解放军第三０二医院; 中国医科大学; 首都医科大学