A randomized controlled trial on the efficacy of resistant dextrin, as functional food, in women with type 2 diabetes: Targeting the hypothalamic-pituitary-adrenal axis and immune system

作者：Farhangi Mandieh Abbasalizad; Javid Ahmad Zare; Sarmadi Bahareh; Karimi Poran; Dehghan Parvin^*

来源：Clinical Nutrition, 2018, 37(4): 1216-1223.

DOI：10.1016/j.clnu.2017.06.005

• Prebiotic
• Brain
• Mental health
• Inflammation
• Immune system
• Type 2 diabetes

Objective: The aim of this trial was to determine the efficacy of a resistant dextrin on immune-mediated inflammation and hypothalamic-pituitary-adrenal axis in women with type 2 diabetes mellitus (T2DM).
Methods: Females (n = 55) with T2DM were randomly allocated into intervention group (n = 30) and control group (n = 25), in which they received 10 g/d of Nutriose (R) 06 (a resistant dextrin) or maltodextrin for 8 weeks, respectively. Fasting blood samples were taken to measure immune system related parameters like white blood cell count, CD4, CD8, interferon-gamma (IFN gamma), interleukins (IL12, 14, 110), cortisol, tryptophan (TRP), ACTH (Adrenocorticotropic hormone), Kynurenine (KYN) and plasma lipopolysaccharide (LPS) at the beginning and end of trial. Mental health was assessed using general health questionnaire (GHQ) and depression, anxiety and stress scale (DASS).
Results: Resistant dextrin caused a significant decrease in levels of cortisol, KYN, KYN/TRP ratio, IFN gamma, IL12, IFN gamma/IL10 ratio, LPS, and a significant increase in the monocyte, GHQ DASS, CD8, IL10, IL4 in the intervention group as compared with baseline. A significant decrease in the level of LPS (-6.20 EU/mL, -17.8%), IFN gamma (-0.6 pg/ml, -26.8%), cortisol (-2.6 mu g/dl, -20.9%), IFN gamma/IL10 ratio (0.01, 10%), GHQ (-5.1, -12.5%), DASS (-10.4, -38.4%), KYN/TRP ratio (6.8, 29.1%), and a significant increase in levels of CD8 (6.4%, 6.1%) and 110 (2.6 pg/ml, 21.6%) in the intervention group as compared with the control group (P < 0.05). No significant changes were observed in white blood cell count, CD4, CD4/CD8 ratio, ACTH, KYN, TRP, IL4 and IL12 in the intervention group as compared with the control group (P > 0.05).
Conclusion: Supplementation of Nutriose (R) 06 may have beneficial effects on mental health and the immune system response in women with T2DM.

• 出版日期2018-8