A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities

作者：Conway Eric; Jerman Emilia; Healy Evan; Ito Shinsuke; Holoch Daniel; Oliviero Giorgio; Deevy Orla; Glancy Eleanor; Fitzpatrick Darren J; Mucha Marlena; Watson Ariane; Rice Alan M; Chammas Paul; Huang Christine; Pratt Kelly Indigo; Koseki Yoko; Nakayama Manabu; Ishikura Tomoyuki; Streubel Gundula; Wynne Kieran; Hokamp Karsten; McLysaght Aoife; Ciferri Claudio; Di Croce Luciano; Cagney Gerard; Margueron Raphael; Koseki Haruhiko; Bracken Adrian P^*

来源：Molecular Cell, 2018, 70(3): 408-+.

DOI：10.1016/j.molcel.2018.03.005

The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 (containing one polycomb-like protein) and PRC2.2 (containing AEBP2 and JARID2), little is known about their differential functions. Here, we report the discovery of a family of vertebrate-specific PRC2.1 proteins, "PRC2 associatedLCORisoform 1'' (PALI1) and PALI2, encoded by the LCOR and LCORL gene loci, respectively. PALI1 promotes PRC2 methyltransferase activity in vitro and in vivo and is essential for mouse development. Pali1 and Aebp2 define mutually exclusive, antagonistic PRC2 subtypes that exhibit divergent H3K27-tri-methylation activities. The balance of these PRC2.1/PRC2.2 activities is required for the appropriate regulation of polycomb target genes during differentiation. PALI1/2 potentially link polycombs with transcriptional co-repressors in the regulation of cellular identity during development and in cancer.

• 出版日期2018-5-3
• 单位RIKEN