Aerobic Oxidation of Sulfides with a Vitamin B-2-Derived Organocatalyst

作者：Imada Yasushi^*; Tonomura Itoko; Komiya Naruyoshi; Naota Takeshi

来源：Synlett, 2013, 24(13): 1679-1682.

DOI：10.1055/s-0033-1339276

• organocatalysis
• aerobic oxidation
• sulfides
• sulfoxides
• flavin catalyst

5-Ethyl-3-methyl-2%26apos;,4%26apos;:3%26apos;,5%26apos;-di-O-methylenedioxy-riboflavinium perchlorate (DMRFlEt(+)ClO(4)(-)) is readily derived from commercially available vitamin B-2 (riboflavin) and exhibits high catalytic activity for the oxidation of organic sulfides under an oxygen atmosphere (1 atm) with the assistance of hydrazine hydrate as a reductant. This is an inexpensive, convenient, and environmentally benign method for the selective oxidative transformation of sulfides into sulfoxides.

• 出版日期2013-8