Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck

作者：van Weert Stijn; Reinhard Rinze; Bloemena Elisabeth; Buter Jan; Witte Birgit I; Vergeer Marije R; Leemans C Rene

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2017, 39(3): 456-463.

DOI：10.1002/hed.24613

• adenoid cystic carcinoma
• head and neck
• distant metastases
• patterns of survival
• solid type histology

Background. We examined the assumption in conventional teaching about metastatic adenoid cystic carcinoma (ACC) being an indolent type of disease.
Methods. A single center analysis of 105 cases of ACC was performed. Radiographs were reviewed and tumor response to chemotherapy was measured. Distant disease-free survival (DDFS) and time to death since distant metastases diagnosis were analyzed.
Results. Forty-two percent of the patients were diagnosed with distant metastases. DDFS showed significant negative associations with advanced T classification, N+ classification, solid type tumor, and positive surgical margins. Distant metastases (91%) developed in the first 5 years after presentation. Median distant metastatic survival was 13.8 months. The most frequent organ sited was the lung. Solid type ACC showed a preponderance for multiorgan metastases (17/28; 61%). Distant metastases seemed not to occur in case of clear surgical margins. Solid type ACC had a significant poorer survival after development of distant metastases.
Conclusion. Metastatic ACC is not always an indolent disease.

• 出版日期2017-3