Pyrroloquinoline quinone prevents MK-801-induced stereotypical behavior and cognitive deficits in mice

作者：Zhou, Xingqin^*; Chen, Quancheng; Hu, Xindai; Mao, Shishi; Kong, Yanyan

来源：Behavioural Brain Research, 2014, 258: 153-159.

DOI：10.1016/j.bbr.2013.10.025

• Pyrroloquinoline quinone
• NMDA receptors
• MK-801
• Stereotypical
• Cognitive deficits

Pyrroloquinoline quinone (PQQ), an essential nutrient, antioxidant, redox modulator, and nerve growth factor, prevents cognitive deficits associated with oxidative stress-induced neurodegeneration. Previous molecular imaging studies also demonstrate that PQQ binds to N-methyl D-aspartate (NMDA) receptors. In this study, we investigated the effects of PQQ on stereotypical behaviors and cognitive deficits induced by MK-801, a non-competitive NMDA antagonist used to model schizophrenia. Mice were given repeated injections of MK-801 (0.5 mg/kg/d) and PQQ (0.2, 2.0, or 20 mu g/kg/d) for 60 days. Behavior was evaluated using a variety of motor, social, and cognitive tests. We found that PQQ administration significantly attenuated MK-801-induced increases in stereotypical behavior and ataxia, suggesting a protective role of PQQ against MK-801-induced neuronal dysfunction and psychiatric disorders. Future studies are necessary to elucidate the underlying mechanisms of PQQ.

• 出版日期2014-1-1
• 单位江苏省原子医学研究所; 华东师范大学