New 3D Supramolecular Ag(I) Coordination Polymer Crystal Containing 2-Quinaldic Acid Radical Biological Ligand: Crystal Structure and Anticancer Activity

作者：Wang, Ren-Shu; Feng, Jing^*; Lei, Yi-Zhu; Chen, Ding-Mei; Lian, Ming-Lei

来源：CRYSTAL RESEARCH AND TECHNOLOGY, 2018, 53(8): 1800065.

DOI：10.1002/crat.201800065

• Ag(I)
• anticancer activity
• coordination polymers
• crystal structure
• Hirshfeld surfaces

A new coordination polymer of {[Ag(Qina)(Bpp)]<bold></bold>(H2O)(2)}(n) (Qina = 2-quinolinecarboxylic-carboxylate, Bpp = 4,4'-trimethylenedipyridine) is successfully synthesized and the structure is determined using single crystal X-ray diffraction. The complex is crystallized in the monoclinic system with P2(1)/c space group: Each atom of Ag(I) is chelated by one Qina group, with each Bpp ligand bridging two Ag(I) atoms to form the 1D polymer chains. Furthermore, the 3D supramolecular architecture is a costructure directed via weak stacking interactions of C-H<bold> and hydrogen bond</bold>. The complex shows competitive binding affinities in calf thymus DNA (ct-DNA) interaction by fluorescence spectroscopy. In addition, the complexes' cytotoxic activity is explored for two kinds of cancer cell lines (Hela, MCF-7), indicating an anticancer activity and cytotoxicity. CCDC: 1553426

• 出版日期2018-8
• 单位六盘水师范学院