A variant within the AQP1 3MODIFIER LETTER PRIME-untranslated region is associated with running performance, but not weight changes, during an Ironman Triathlon

作者：Saunders Colleen J; Posthumus Michael; O' Connell Kevin; September Alison V; Collins Malcolm

来源：Journal of Sports Sciences, 2015, 33(13): 1342-1348.

DOI：10.1080/02640414.2014.989535

• athletic performance
• body fluids
• aquaporin 1
• water channel proteins

The objective of this study was to test the association of the rs1049305 (G>C) variant within the 3MODIFIER LETTER PRIME-untranslated region of the aquaporin 1 gene, AQP1, with changes in body weight, post-race serum sodium concentration and performance in Ironman triathletes. Five hundred and four male Ironman triathletes were genotyped for the rs1049305 variant within the AQP1 gene. Change in pre- and post-race body weight was calculated for 470 triathletes and used as a proxy for changes in body fluid during the race, as well as to divide triathletes into biologically relevant weight-loss groups (0-3%, 3-5% and >5%). There were no rs1049305 genotype effects on post-race serum sodium concentrations (P=0.647), pre-race weight (P=0.610) nor relative weight change during the Ironman Triathlons (P=0.705). In addition, there were no significant differences in genotype (P=0.640) nor allele (P=0.643) distributions between the weight loss groups. However, triathletes who carry a C-allele were found to complete the 42.2-km run stage faster (mean 286, s=49min) than triathletes with a GG genotype (mean 296, s=47min; P=0.032). The AQP1 rs1049305 variant is associated with running performance, but not relative body weight change, during the 2000, 2001 and 2006 South African Ironman Triathlons.

• 出版日期2015-8-9