A novel partial volume correction method for accurate quantification of [F-18] flortaucipir in the hippocampus

作者：Wolters Emma E; Golla Sandeep S V^*; Timmers Tessa; Ossenkoppele Rik; van der Weijden Chris W J; Scheltens Philip; Schwarte Lothar; Schuit Robert C; Windhorst Albert D; Barkhof Frederik; Yaqub Maqsood; Lammertsma Adriaan A; Boellaard Ronald; van Berckel Bart N M

来源：EJNMMI Research, 2018, 8(1): 79.

DOI：10.1186/s13550-018-0432-2

Background: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [F-18] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC).
Methods: PVC was performed on 20 [F-18] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (V-T), with and without PVC, was determined. Both anatomically defined and eroded VOIs were used.
Results: For controls, the correlation between hippocampal and CP V-T was significantly reduced after using PVC along with an eroded VOI (r(2) = 0.59, slope = 0.80 versus r(2) = 0.15, slope = 0.15; difference: p < 0.05). The same was true for AD patients (p < 0.05).
Conclusion: PVC together with an optimized hippocampal VOI resulted in effective reduction of CP spill-in and improved accuracy of hippocampal V-T.

• 出版日期2018-8-15