Drug-Induced Nephrotoxicity in Inflammatory Bowel Disease

作者：Oikonomou Konstantinos A^*; Kapsoritakis Andreas N; Stefanidis Ioannis; Potamianos Spyros P

来源：Nephron Clinical Practice, 2011, 119(2): C89-C95.

DOI：10.1159/000326682

• Inflammatory bowel disease
• Nephrotoxicity
• Tubulointerstitial nephritis
• Glomerulonephritis
• Aminosalicylates
• Cyclosporine
• Tumor necrosis factor-alpha inhibitors

Conservative management of inflammatory bowel disease (IBD) is based on a combination of drugs, including amino-salicylates (ASAs), steroids, antibiotics, immunosuppressives and biologic agents. Although various side effects have been related to treatment regimens, drug-induced nephrotoxicity is rather uncommon. Furthermore, it is often underestimated since renal function deterioration may be attributed to the underlying disease. The nephrotoxicity of ASAs and cyclosporine A seems well established, but recent data have suggested a possible role of biologic agents such as infliximab and adalimubab in renal impairment. The aim of this review is to summarize the nephrotoxic effects of medical treatment as well as to express possible caveats in the administration of novel agents in IBD.

• 出版日期2011