A rapid and selective fluorescent probe with a large Stokes shift for the detection of hydrogen sulfide

作者：Chen, Song^*; Hou, Peng; Wang, Jing; Fu, Shuang; Liu, Lei

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2018, 203: 258-262.

DOI：10.1016/j.saa.2018.05.108

• Large Stokes shift
• Fluorescent probe
• Cell imaging
• Hydrogen sulfide

We have successfully developed a new green-emitting H2S fluorescence probe employing a 2,4-dinitrophenyl ether moiety as the sensing group based on 3'-formyl-4'-hydroxybiphenyl-4-carbonitrile. This probe displayed a rapid (2 min), sensitive (the detection limit was 0.18 mu M) and selective with a large Stokes shift (183 nm) in response to H2S, which was beneficial for fluorescence sensing and cell imaging studies. Moreover, this probe can qualitatively and quantitatively detect H2S with a good linearity (R-2 = 0.9991). Importantly, this probe had been used for the detection of H2S in living MDA-MB-231 cells with good performance.

• 出版日期2018-10-5
• 单位齐齐哈尔医学院