Dimethyl-beta-cyclodextrin/salazosulfapyridine inclusion complex-loaded chitosan nanoparticles for sustained release

作者：Tang, Peixiao; Yang, Hongqin; Tang, Bin; Wu, Di; Du, Qiaohong; Xu, Kailin; Li, Hui^*

来源：Carbohydrate Polymers, 2017, 156: 215-222.

DOI：10.1016/j.carbpol.2016.09.038

• Salazosufapyridine
• 2,6-dimethyl-beta-cyclodextrin
• Chitosan
• Nanoparticles
• Sustained release

This study aimed to investigate a novel delivery system for salazosulfapyridine (SASP) through encapsulation in 2,6-dimethyl-beta-cyclodextrin (DM beta CD) and further incorporation in chitosan (CS) to form nanoparticles (NPs). The inclusion complex of SASP and DM beta CD was prepared at 1:1 host-guest stoichiometry based on Job's plot and then characterized through various analytical techniques. Then, the DM beta CD/SASP inclusion complex was incorporated in CS to form DM beta CD/SASP/CS NPs. The loading efficiency of SASP in the DM beta CD/SASP/CS NPs was significantly higher than that of the SASP/CS NPs. A positive zeta potential of +35.4 mV was also observed in the DM beta CD/SASP/CS NPs with an average size of 90 nm. SASP exhibited a sustained release after the DM beta CD/SASP/CS NPs were formed. The toxicity of the NPs to LO2 cells was lower than that of free SASP. Therefore, the CD inclusion complex-loaded CS NPs can be applied to deliver hydrophobic drugs.

• 出版日期2017-1-20
• 单位四川大学