A Review on Steroidal 5 alpha-Reductase Inhibitors for Treatment of Benign Prostatic Hyperplasia

作者：Sun J; Xiang H^*; Yang L L; Chen J B

来源：Current Medicinal Chemistry, 2011, 18(23): 3576-3589.

• 5 alpha-Reductase
• 5 alpha-reductase inhibitors
• benign prostatic hyperplasia
• dihydrotestosterone
• steroid
• finasteride
• azasteroid
• 3-carboxylic acid
• pregnane derivatives
• natural products

Benign prostatic hyperplasia (BPH) is a kind of common noncancerous prostate gland enlargement with growing tendency in recent years. 5 alpha-reductase is the key enzyme responsible for dihydrotestosterone biosynthesis and has been considered as an important target for designing inhibitors as potent therapeutic agents for BPH. Finasteride, the first steroidal 5 alpha-reductase inhibitor, has been marketed worldwide as a drug for BPH. During these years, many other novel types of 5 alpha-reductase inhibitors are being studied. This review summarizes recent advancement in steroidal 5 alpha-reductase inhibitors.

• 出版日期2011-8
• 单位中国药科大学