Ultrasonographic assessment of skin thickness in patients with PCOS - a case-control study

作者：Boettcher B; Stahlhofer K J; Mattle V; Seeber B; Brezinka C^*; Wildt L

来源：Gynecological Endocrinology, 2013, 29(4): 380-383.

DOI：10.3109/09513590.2012.752453

• Collagen content
• estrogen
• polycystic ovary syndrome
• skin thickness
• testosterone

Objective: To measure skin thickness in patients with polycystic ovary syndrome (PCOS) in comparison to controls and to examine a possible association with sex steroids, body mass index, lipid profile and hyperinsulinemia. %26lt;br%26gt;Methods: Thirty patients with confirmed PCOS were compared to thirty-two women presenting for infertility workup. Skin thickness was measured using high-resolution ultrasound in a standardized area, blood samples were collected once at presentation. %26lt;br%26gt;Results: Patients with PCOS showed a statistically significant thicker skin than women in the control group (0.95 mm (+/- 0.093 mm) versus 0.85 mm (+/- 0.077 mm, p%26lt;0.0001)). LH, estradiol, testosterone, the free androgen index, triglycerides, cholesterol, LDL-cholesterol and body mass index were significantly increased in PCOS - patients. No correlation between hyperinsulinemia and skin thickness was seen. %26lt;br%26gt;Conclusions: PCOS - patients showed a greater skin thickness in comparison to women without PCOS. This might be due to proliferative effects of sex steroids such as estrogens and testosterone and metabolic derangements on skin thickness.

• 出版日期2013-4