A New Class of Synthetic Peptide Inhibitors Blocks Attachment and Entry of Human Pathogenic Viruses

作者：Krepstakies Marcel; Lucifora Julie; Nagel Claus Henning; Zeisel Mirjam B; Holstermann Barbara; Hohenberg Heinrich; Kowalski Ina; Gutsmann Thomas; Baumert Thomas F; Brandenburg Klaus; Hauber Joachim; Protzer Ulrike^*

来源：Journal of Infectious Diseases, 2012, 205(11): 1654-1664.

DOI：10.1093/infdis/jis273

Many enveloped viruses, including herpes viruses, hepatitis B virus (HBV), and hepatitis C virus (HCV), and human immunodeficiency virus (HIV), are among the most important human pathogens and are often responsible for coinfections involving %26gt;= 2 types of viruses. However, therapies that are effective against multiple virus classes are rare. Here we present a new class of synthetic anti-lipopolysaccharide peptides (SALPs) that bind to heparan sulfate moieties on the cell surface and inhibit infection with a variety of enveloped viruses. We demonstrate that SALPs inhibit entry of human immunodeficiency virus type 1 (HIV-1), herpes simplex virus (HSV) 1 and 2, HBV, and HCV to their respective host cells. Despite their high antiviral efficiency, SALPs were well tolerated, and neither toxicity nor measurable inhibitor-induced adverse effects were observed. Since these broad-spectrum antiviral peptides target a host cell rather than a viral component, they may also be useful for suppression of viruses that are resistant to antiviral drugs.

• 出版日期2012-6-1