Association of vascular invasion with increased mortality in patients with minimally invasive follicular thyroid carcinoma but not widely invasive follicular thyroid carcinoma

作者：Kim Hye Jeong; Sung Ji Youn; Oh Young Lyun; Kim Jung Han; Son Young Ik; Min Yong Ki; Kim Sun Wook; Chung Jae Hoon^*

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2014, 36(12): 1695-1700.

DOI：10.1002/hed.23511

• thyroid cancer
• follicular
• vascular invasion
• prognosis
• survival

BackgroundThe association of vascular invasion with tumor aggressiveness and poor prognosis in follicular thyroid carcinoma (FTC) remains controversial. %26lt;br%26gt;MethodsWe reviewed medical records of 204 patients with histologically confirmed FTC. %26lt;br%26gt;ResultsThe disease-specific survival rates at 5 and 10 years were 94% and 85%, respectively. Using Cox proportional hazard model, the extent of invasiveness and the frequency of distant metastasis were found to be independent prognostic factors for survival in all patients with FTC. When we performed individual analyses stratified by the extent of invasiveness, vascular invasion was an independent predictor of disease-specific survival in minimally invasive FTC, but that did not independently affect survival in widely invasive FTC. %26lt;br%26gt;ConclusionThis study suggests that vascular invasion is associated with aggressive features of FTC and independently influences outcomes in minimally invasive FTC. For patients aged %26lt;45 years with minimally invasive FTC without vascular invasion, thyroid lobectomy alone may be adequate.

• 出版日期2014-12