Angiotensin Converting Enzyme Inhibition Activity of Fennel and Coriander Oils from India

作者：Chaudhary Sushil Kumar; Maity Niladri; Nema Neelesh Kumar; Bhadra Santanu; Saha Bishnu Pada; Mukherjee Pulok Kumar^*

来源：Natural Product Communications, 2013, 8(5): 671-672.

• ACE inhibitor
• Fennel oil
• Coriander oil
• Linalool
• Anethole

Foeniculum vulgare Mill and Coriandrum sativum L. are very popular spices in Indian kitchens. The present study was an attempt to evaluate the angiotensin converting enzyme (ACE) inhibition and antioxidant activity of the standardized oils of F. vulgare and C. sativum by an UV method using hippuryl-L-histidyl-L-leucine (HHL) as substrate. Standardization of the oils and identification of the chemical-markers (linalool and anethole) present in them was performed through HPLC and GC-MS. Coriander oil showed the higher ACE inhibition with an IC50 value of 34.8 +/- 2.3 mu g/mL, than fennel oil with an IC50 value of 40.7 +/- 3.5 mu g/mL. Both oils showed strong DPPH radical scavenging activity. This finding suggests that coriander and fennel oils can be potential leads for the management of hypertension as an ACE inhibitor.

• 出版日期2013-5