Acute-onset chronic inflammatory demyelinating polyneuropathy with focal segmental glomerulosclerosis

作者：Quek Amy May Lin; Soon Derek; Chan Yee Cheun; Thamboo Thomas Paulraj; Yuki Nobuhiro^*

来源：Journal of the Neurological Sciences, 2014, 341(1-2): 139-143.

DOI：10.1016/j.jns.2014.03.040

• Autoimmune disease
• Chronic inflammatory demyelinating polyneuropathy
• Focal segmental glomerulosclerosis
• Guillain-Barre syndrome
• Nephrotic syndrome
• Peripheral neuropathy

Inflammatory neuropathies have been reported to occur in association with nephrotic syndrome. Their underlying immuno-pathogenic mechanisms remain unknown. A 50-year-old woman concurrently presented with acute-onset chronic inflammatory demyelinating polyneuropathy and nephrotic syndrome secondary to focal segmental glomerulosclerosis. Both neuropathy and proteinuria improved after plasma exchange and steroids. Literature review of cases of concurrent inflammatory neuropathies and nephrotic syndrome revealed similar neuro-renal presentations. This neuro-renal condition may be mediated by autoantibodies targeting myelin and podocytes.

• 出版日期2014-6-15