Understanding the role of tyrosine in glycogenin

作者:Camiruaga Ander; Usabiaga Imanol; Insausti Aran; Cocinero Emilio J; Leon Iker*; Fernandez Jose A*
来源:Molecular Biosystems, 2017, 13(9): 1709-1712.
DOI:10.1039/c7mb00293a

摘要

We explored the molecular basis of tyrosine as the docking amino acid for the first glucose molecule during the synthesis of glycogen. The IR spectra show that the aromatic ring acts as bait to keep the position where the next glucose unit has to bind clear, by luring non-desirablemolecules towards the aromatic ring. Only, alpha-/beta-glucose shows particular affinity for the O3H and O4H moieties.

  • 出版日期2017-9-1