Development of gemcitabine-adsorbed magnetic gelatin nanoparticles for targeted drug delivery in lung cancer

作者：Sanlier Senay Hamarat^*; Yasa Merve; Cihnioglu Asli Ozge; Abdulhayoglu Merve; Yilmaz Habibe; Ak Guliz

来源：Artificial Cells Nanomedicine and Biotechnology, 2016, 44(3): 943-949.

DOI：10.3109/21691401.2014.1001493

• adsorption
• drug delivery
• gemcitabine
• isotherm
• kinetic modeling
• magnetic gelatin nanoparticles

Magnetic iron oxide nanoparticles (IONPs) were coated with gelatin type B by means of the two-step desolvation method. Drug loading by adsorption was studied under various conditions such as different temperature, contact time, pH, and initial gemcitabine concentration. Further, Langmuir isotherm curves were constracted and constants were calculated. According to the Langmuir isotherm, the Gibbs free energy of the adsorption process at 25 degrees C was - 4.74 kJ/mol. On the other hand, this value at 37 degrees C was - 7.86 kJ/mol. In vitro drug release was performed at pH levels of 5 and 7.4, with gemcitabine-loaded magnetic gelatin nanoparticles and free gemcitabine, and both the results were subsequently compared.

• 出版日期2016-5