Asymmetric hydrogenation of quinolines catalyzed by iridium complexes of monodentate BINOL-derived phosphoramidites

作者：Mrsic Natasa; Lefort Laurent; Boogers Jeroen A F; Minnaard Adriaan J^*; Feringa Ben L; de Vries Johannes G

来源：Advanced Synthesis & Catalysis, 2008, 350(7-8): 1081-1089.

DOI：10.1002/adsc.200800007

• asymmetric hydrogenation
• homogeneous catalysis
• iridium
• phosphoramidites
• quinolines

The monodentate BINOL-derived phosphoramidite PipPhos is used as ligand for the iridium-catalyzed asymmetric hydrogenation of 2- and 2,6-substituted quinolines. If tri-ortho-tolylphosphine and/or chloride salts are used as additives enantioselectivities are strongly enhanced up to 89%. NMR indicates that no mixed complexes are formed upon addition of tri-ortho-tolylphosphine.

• 出版日期2008-5