Antioxidant, Cytotoxic and alpha-Glucosidase Inhibitory Activities of Compounds isolated from the Twig Extracts of Maclura fruticosa

作者：Polbuppha Isara****; Maneerat Wisanu; Sripisut Tawanun; Limtharakul Thunwadee; Cheenpracha Sarot; Pyne Stephen G; Muanprasat Chatchai; Seemakhan Sawinee; Borwornpinyo Suparerk; Laphookhieo Surat^*

来源：Natural Product Communications, 2017, 12(7): 1073-1076.

DOI：10.1177/1934578x1701200718

• Maclura fruticosa
• Moraceae
• Xanthone
• Isoflavone
• Antioxidant activity
• alpha-Glucosidase inhibitory
• Cytotoxicity

The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, alpha-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC50 values ranging from 7.45-16.12 mu M. Compound 4 also exhibited potent activity against ABTS(.+) scavenging activity with an IC50 value of 0.55 +/- 0.01 mu M which was better than positive control (ascorbic acid, IC50 2.35 +/- 0.17 mu M). Compound 12 showed significant alpha-glucosidase inhibitory activity with an IC50 value of 0.02 +/- 0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC50 values ranging from 22.35-47.62 mu M.

• 出版日期2017-7