Assessment of bone morphogenic protein and hydroxyapatite-titanium dioxide composites for bone implant materials

作者：Chen Hsien Te; Shu Hui Ying; Chung Chi Jen^*; He Ju Liang

来源：Surface and Coatings Technology, 2015, 276: 168-174.

DOI：10.1016/j.surfcoat.2015.06.056

• Titanium
• Micro-arc oxidation (MAO)
• Hydroxyapatite-titanium dioxide (HAp-TiO2)
• Physical adsorption
• Bone morphogenetic protein-2 (BMP-2)

The HAp-TiO2 coating, made by micro-arc oxidation (MAO), is successfully grown on the Ti surface in one step; BMP-2 growth factor is physically immobilized on the HAp-TiO2 coating. The BMP-2/HAp-TiO2 hybrid system outperforms systems of pure Ti, BMP-2/Ti, and HAp-TiO2 by promoting cell adhesion increasing filopodia and polygonal lamellipodia extension, and increasing cell viability. Additionally, cell proliferation and alkaline phosphatase (ALP) activity both indicate that the BMP-2/HAp-TiO2 hybrid system is more successful. According to the characteristics of mechanical support from HAp-TiO2, the BMP-2/HAp-TiO2 hybrid system can maintain a stable release rate of BMP-2 to promote bone cell growth and rapidly heal the bone-implant interface. The new BMP-2/HAp-TiO2 hybrid system developed in this study can be expected to contribute in the application of orthopedic and dental implants.

• 出版日期2015-8-25
• 单位中国医科大学