科研之友
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摘要
Background Correct interpretation of blood pressure (BP) and heart rate (HR) recordings is important in a clinical environment, but little is known about effects of stress on BP and HR responses of dogs to different clinical settings. %26lt;br%26gt;Objective To investigate BP and HR responses in different clinical settings in dogs of 3 breeds, and to relate findings to urinary catecholamine concentrations measured by ELISA assays previously validated for use in human plasma and urine, after validation for use in dogs. %26lt;br%26gt;Animals Client-owned healthy dogs; 41 Labrador Retrievers, 33 Cavalier King Charles Spaniels (CKCS), and 15 Dachshunds. %26lt;br%26gt;Methods Prospective observational study. BP and HR were measured in 4 clinical settings with or without veterinarian and owner present. Urine samples were taken before and after examination. ELISA assays were validated for canine urine, and epinephrine/creatinine and norepinephrine/creatinine ratios were analyzed. %26lt;br%26gt;Results BP and HR were higher when measured by veterinarian alone than when owner was present (P %26lt; .020). Urinary catecholamine/creatinine ratios were higher after examination, compared with before, in all dogs (P %26lt; .0001). Labrador Retrievers had lower diastolic BP than Dachshunds in 2 settings (P = .041), lower HR than CKCSs in 3 settings (all P %26lt; .0001), and lower catecholamine/creatinine ratios after examination than both other breeds (P = .035). The in-house validation showed mean spiked recovery of 96.5% for epinephrine and 83.8% for norepinephrine. %26lt;br%26gt;Conclusions and Clinical Importance BP and HR responses were related to breed as well as clinical setting. Breed differences were detected in urinary catecholamine/creatinine ratios. Further studies on breed differences are warranted.
- 出版日期2012-12
