The Correlation between CVR-R and Carotid Atherosclerosis in Type 2 Diabetes Mellitus Patients with Diabetic Neuropathy

作者：Miyamoto Michiaki; Kotani Kazuhiko^*; Yagyu Hiroaki; Koibuchi Harumi; Fujii Yasutomo; Konno Kei; Yamada Toshiyuki; Ishibashi Shun; Taniguchi Nobuyuki

来源：Journal of Physiological Anthropology, 2010, 29(4): 149-152.

DOI：10.2114/jpa2.29.149

• CVR-R difference
• diabetic autonomic neuropathy
• intima-media thickness
• atherosclerosis

We examined the relationship between the coefficient of variation in the R-R intervals (CVR-R) using electrocardiograms and the ultrasonic intima-media thickness (IMT) of the carotid artery, an atherosclerotic parameter, in type 2 diabetes mellitus (DM) patients with diabetic neuropathy (n=47, males/females: 29/18; mean age: 62 years). In this study, the CVR-R-related indexes, including CVR-R at rest (CVR-R(rest)), CVR-R with deep breaths (CVR-R(breath)) and their difference (CVR-R(breath), minus CVR-R(rest): CVR-R(dif)), were defined. Data such as body mass index, smoking habits, hemoglobin A1c, blood pressure, and serum low-density lipoprotein were collected. A significant inverse correlation was observed between max-IMT and CVR-R(dif) (beta=-0.34, p=0.042), but not CVR-R(rest) or CVR-R(breath), in multivariate analyses adjusted for all the data. Therefore, the CVR-R(dif) may serve as a clinical index for the diabetic autonomic neuropathy-atherosclerosis relation in type 2 DM patients. Physiol Anthropol 29(4): 149-152, 2010 http://www.jstage.jst.go.jp/browse/jpa2 [DOI: 10.2114/jpa2.29.149]

• 出版日期2010-7