Determinants of the quality of life in Parkinson's disease: Results of a cohort study from Southwest China

作者：Wu, Ying; Guo, Xiao Yan; Wei, Qian Qian; Song, Wei; Chen, Ke; Cao, Bei; Ou, Ru Wei; Zhao, Bi; Shang, Hui Fang^*

来源：Journal of the Neurological Sciences, 2014, 340(1-2): 144-149.

DOI：10.1016/j.jns.2014.03.014

• Parkinson disease
• Quality of life (QoL)
• Non-motor symptoms (NMS)
• Motor severity
• Determinants
• PDQ-39

Background: The determinants of the quality of life (QoL) of patients with Parkinson's disease (PD) in Chinese population remain largely unknown. @@@ Methods: A total of 649 PD patients from Southwest China participated in this cross-sectional study. Non-motor Symptoms Scale (NMSS) was used to evaluate the non-motor symptoms (NMS), whereas PD Quality of Life Questionnaire (PDQ-39) was used to assess the QoL of the PD patients. Multiple stepwise regression analysis was conducted to identify the determinants of the QoL. @@@ Results: NMS, H-Y stage, female, disease duration, UPDRS III score, single/divorced/widowed, and motor complications accounted for 66.3% of the variables in the multiple regression analysis and were the negative determinants of the QoL. Among these variables, NMS and H-Y stage accounted for 46.7% and 14.5%, respectively. NMS were closely associated with each domain of PDQ-39. Female sex especially predicted poor emotional well-being and bodily discomfort, whereas single/divorced/widowed especially predicted poor stigma and social support of PD patients. Comorbidity, motor complications and rural living predicted poor mobility, activities of daily living and emotional well-being, respectively. @@@ Conclusion: Both demographic and disease-specific factors influence the QoL in PD patients. NMS are the strongest independent negative determinant of the overall QoL and closely associated with each domain of PDQ-39. The treatment of NMS may help to improve the QoL of PD patients.

• 出版日期2014-5-15
• 单位四川大学