High Prevalence of High Grade Anal Intraepithelial Neoplasia in HIV-Infected Women Screened for Anal Cancer

作者：Hou June Y; Smotkin David; Gros**erg Robert; Suhrland Mark; Levine Rebecca; Smith Harriet O; Negassa Abdissa; McAndrew Thomas C; Einstein Mark H^*

来源：JAIDS: Journal of Acquired Immune Deficiency Syndromes , 2012, 60(2): 169-172.

DOI：10.1097/QAI.0b013e318251afd9

• anal cancer screening
• anal cytology
• high-resolution anoscopy
• HPV-associated disease

There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.

• 出版日期2012-6-1