MRI-measured myocardial iron load in patients with severe diabetic heart failure

作者：Wang, B.; Zhang, Y.; Sun, N.; Gu, S.; Ding, F.; Xu, S.; Zhou, H.^*; Liu, Y.^*

来源：Clinical Radiology, 2018, 73(3): 324.e1-324.e7.

DOI：10.1016/j.crad.2017.10.012

• VENTRICULAR FUNCTION
• MAGNETIC-RESONANCE
• ENERGY-METABOLISM
• ASSOCIATION
• HOMEOSTASIS
• DYSFUNCTION
• DEPOSITION
• MELLITUS
• HEPCIDIN

AIM: To investigate whether a correlation exists between abnormal myocardial iron status and cardiac lipid deposition as well as other biomarkers in patients with diabetic heart failure (DHF). @@@ MATERIALS AND METHODS: Seventeen volunteers (Group 1), 26 patients with non-severe DHF (Group 2), and 25 patients with severe DHF (Group 3) were recruited for this study. Myocardial middle-section T2* mapping and septal H-1 magnetic resonance spectroscopy (H-1-MRS) were performed using a 3 T magnetic resonance imaging (MRI) machine to assess the iron status and lipid deposition individually. Fasting venous blood was used to examine serum biomarkers. @@@ RESULTS: Cardiac T2* (ms) of the three groups were 22.8 +/- 2.1, 21.7 +/- 1.8, and 18.6 +/- 1.3, respectively. The value of Group 3 was significantly lower than that of the other two groups (p<0.001). Myocardial triglyceride (%) levels differed among the three groups (Group 1, 0.53 +/- 0.13; Group 2, 1.11 +/- 0.29; Group 3, 1.47 +/- 0.12; p< 0.001). Cardiac T2* was inversely correlated with both cardiac triglycerides and left ventricular ejection fraction (LVEF) in overall participants (Groups 1-3) or Group 3 (each p<0.001). @@@ CONCLUSIONS: Abnormal myocardial iron status was found in patients with severe diabetic heart failure. Myocardial lipotoxicity may be responsible for this process.

• 出版日期2018-3
• 单位复旦大学; 山东省医学影像学研究所; 山东大学