A new, pachymetry-based approach for diagnostic cutoffs for normal, suspect and keratoconic cornea

作者：Prakash G; Agarwal A^*; Mazhari A I; Kumar G; Desai P; Kumar D A; Jacob S; Agarwal A^*

来源：Eye, 2012, 26(5): 650-657.

DOI：10.1038/eye.2011.365

• keratoconus
• keratoconus suspect
• cutoffs
• pachymetry
• keratometry

Purpose To analyze whether an association exists between keratometric and pachymetric changes in the cornea, and whether it can be used to create pachymetric cutoff criteria secondary to keratometric criteria.
Methods In this cross-sectional study, 1000 candidates presenting to the refractive surgery services of a tertiary care hospital underwent bilateral Orbscan IIz (Bausch and Lomb) assessment along with other ophthalmic evaluation.
Results Stepwise regression analysis-based models showed that simulated keratometry (simK) astigmatism was significantly predicted by the minimum corneal thickness (MCT) and difference between central and MCT (delta CT), mean SimK by the MCT and delta CT, and maximum keratometry in the central 10-mm zone by the MCT and delta CT (P < 0.001). The mean MCT values were 542.5 +/- 39.6, 539.9 +/- 39.2, 524.2 +/- 49.5, and 449.3 +/- 73.7 mu m for flatter normal (< 44 D), steeper normal (>= 44 D), keratoconus suspect and keratoconic eyes, respectively (P < 0.001). The mean differences between central corneal thickness and MCT (delta CT) were 12.2 +/- 7.1 mu m, 12.4 +/- 7.4 mu m, 14.4 +/- 8.9 mu m and 23.2 +/- 10.1 mu m for the flatter normal, steeper normal, keratoconus suspect, and keratoconic eyes, respectively (P < 0.001). Mean and 2SD cutoff were used to suggest that a cornea having MCT < 461 mu m or delta CT > 427 mu m has only a 2.5% chance of being normal and not a keratoconus suspect or worse.
Conclusion Pachymetric diagnostic cutoffs can be used as adjuncts to the existing topographic criteria to screen keratoconus suspect and keratoconic eyes. Eye (2012) 26, 650-657; doi:10.1038/eye.2011.365; published online 27 January 2012

• 出版日期2012-5