Autologous nerve graft repair of different degrees of sciatic nerve defect: stress and displacement at the anastomosis in a three-dimensional finite element simulation model

作者：Piao, Cheng-dong; Yang, Kun; Le, Peng; Luo, Min^*

来源：Neural Regeneration Research, 2015, 10(5): 804-807.

DOI：10.4103/1673-5374.156986

• nerve regeneration
• sciatic nerve injury
• autologous nerve grafting
• epineurial suturing
• three-dimensional finite element models
• load
• stress
• displacement
• neural regeneration

In the repair of peripheral nerve injury using autologous or synthetic nerve grafting, the magnitude of tensile forces at the anastomosis affects its response to physiological stress and the ultimate success of the treatment. One-dimensional stretching is commonly used to measure changes in tensile stress and strain; however, the accuracy of this simple method is limited. Therefore, in the present study, we established three-dimensional finite element models of sciatic nerve defects repaired by autologous nerve grafts. Using PRO E 5.0 finite element simulation software, we calculated the maximum stress and displacement of an anastomosis under a 5 N load in 10-, 20-, 30-, 40-mm long autologous nerve grafts. We found that maximum displacement increased with graft length, consistent with specimen force. These findings indicate that three-dimensional finite element simulation is a feasible method for analyzing stress and displacement at the anastomosis after autologous nerve grafting.

• 出版日期2015-5
• 单位吉林大学; 中国人民解放军空军航空大学