Astrocyte elevated gene-1 induces breast cancer proliferation and invasion through upregulating HER2/neu expression

作者：Zhang Xin^*; Zhang Ning; Zhang Mei-xin

来源：Chinese Medical Journal, 2011, 124(21): 3546-3550.

DOI：10.3760/cma.j.issn.0366-6999.2011.21.020

• astrocyte elevated gene-1
• HER2/neu
• invasion
• breast cancer

Background Astrocyte elevated gene-1 (AEG-1), primarily identified as a late response gene induced by HIV-1 infection, plays multiple roles in the process of oncogenesis. This novel gene has been demonstrated to be involved in the several potent carcinogenic pathways, including PI3K/Akt pathway, nuclear factor (NF)-kappa B pathway, and Wnt/beta-catenin pathway. Although the function of AEG-1 has been intensively investigated in recent years, the molecular mechanism underlying its oncogenic role is largely unknown. The aim of this research was to explore the potential function of AEG-1 in breast cancer development and progression. @@@ Methods AEG-1 was ectopically overexpressed in breast cancer MCF-7 cells and its biological effects on the proliferation and invasion of MCF-7 cells were studied by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MU) and invasion assays. The expression of HER2/neu, a crucial oncogene involving in breast cancer carcinogenesis, was also determined. @@@ Results Overexpression of the AEG-1 promoted the proliferation and invasion ability of breast cancer cells, and upregulated the expression of HER2/neu, a crucial oncogene involving in breast cancer carcinogenesis. @@@ Conclusion AEG-1 might facilitate the proliferation and invasion of breast cancer cells by upregulating HER2/neu expression, which provides a potential target for breast cancer therapy. Chin Med J 2011;124(21):3546-3550

• 出版日期2011-11-5
• 单位山东大学