Antiplatelet and Thermally Responsive Poly(N-isopropylacrylamide) Surface with Nanoscale Topography

作者：Chen Li; Liu Mingjie; Bai Hao; Chen Peipei; Xia Fan; Han Dong^*; Jiang Lei

来源：Journal of the American Chemical Society, 2009, 131(30): 10467-10472.

DOI：10.1021/ja9019935

Nanoscale topography was constructed on a thermally responsive poly(N-isopropylacrylamide) (PNIPAAm) surface by grafting the polymer from silicon nanowire arrays via surface-initiated atom transfer radical polymerization. The as-prepared surface showed largely reduced platelet adhesion in vitro both below and above the lower critical solution temperature (LCST) of PNIPAAm (similar to 32 degrees C), while a smooth PNIPAAm surface exhibited antiadhesion to platelets only below the LCST. Contact angle and adhesive force measurements on oil droplets (1,2-dichloroethane) in water demonstrated that the nanoscale topography kept a relatively high ratio of water content on the as-prepared-surface and played a key role in largely reducing the adhesion of platelets; however, this effect did not exist on the smooth PNIPAAm surface. The results can be used to extend the applications of PNIPAAm in the fields of biomaterials and biomedicine under human physiological temperature and provide a new strategy for fabricating other blood-compatible materials.

• 出版日期2009-8-5
• 单位中国科学院; 国家纳米科学中心