Access to bicyclic hydroxamate macrocycles via intramolecular aza-(4+3) cyloaddition reactions of aza-oxyallylic cation intermediates

作者：Acharya A; Eickhoff J A; Chen K; Catalano V J; Jeffrey C S^*

来源：Organic Chemistry Frontiers, 2016, 3(3): 330-334.

DOI：10.1039/c5qo00315f

The intramolecular aza-(4 + 3) cycloaddition reactions of in situ generated aza-oxyallylic cations and furans have been reported for the construction of medium sized hydroxamate macrocycles. This method provides direct access to 12-18 membered bicyclic macrocycles. The highly functionalized macrocycles have been transformed easily in to a wide range of highly functionalized heterocyclic scaffolds including lactones and lactams that could serve the synthesis of complex macrocyclic natural products and pharmaceuticals.

• 出版日期2016