An expedient synthesis of N-tosyl macrocycles containing two thiourea moieties from trisulfonamide and bis-dithiocarbamate salts at room temperature in aqueous media

作者：Ding Congwen; Zhang Mingjie^*; Geng Lijun; Li Ruimin

来源：ARKIVOC, 2010, 49-54.

• Trisulfonamide
• activated bis-dithiocarbamate salt
• N-tosyl-macrocycle containing two thiourea moieties
• green synthesis

The nucleophilic reaction of diamines and carbon disulfide in aqueous NaOH afforded a series of bis-dithiocarbamate salts. Activation of these with aqueous ClCH(2)COOK and subsequent nucleophilic substitution reaction with trisulfonamide aqueous KOH at room temperature provided N-tosyl-macrocycles containing two thiourea units. This strategy has the advantages of simple operation, mild reaction condition, easy product-isolation and environmental friendliness.

• 出版日期2010
• 单位天津大学