Lanthanides-Induced Cellular Signal Transduction: Implications in Pathogenesis of Fibrosis

作者:HE Xia; GUO Yuting; DONG Faqing; WANG Kui; YU Siwang
来源:矿物学报, 2013, S1: 34.
DOI:10.16461/j.cnki.1000-4734.2013.s1.063

摘要

With the extensive mining and application of lanthanides in China and worldwide, the potential impact of lanthanides on human health is gaining increasing attentions. The recent etiological association of gadolinium-based contrast agents with nephrogenic systemic fibrosis (NSF) evoked widespread concerns regarding the safety issue of lanthanides. The elucidation of the cellular biological effects of and the signalling cascade induced lanthanides is essential for proper evaluation of their health impacts.

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