Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation

作者：Zhang, Weixin; Yin, Lianhong; Tao, Xufeng; Xu, Lina; Zheng, Lingli^*; Han, Xu; Xu, Youwei; Wang, Changyuan; Peng, Jinyong^*

来源：Environmental Toxicology and Pharmacology, 2016, 45: 193-201.

DOI：10.1016/j.etap.2016.06.002

• Dioscin
• DMN
• Liver injury
• Apoptosis
• Oxidative stress
• Inflammation

In our previous study, the effects of dioscin against alcohol-, carbon tetrachloride- and acetaminophen induced liver damage have been found. However, the activity of it against dimethylnitrosamine (DMN)-induced acute liver injury remained unknown. In the present study, dioscin markedly decreased serum ALT and AST levels, significantly increased the levels of SOD, GSH-Px, GSH, and decreased the levels of MDA, iNOS and NO. Mechanism study showed that dioscin significantly decreased the expression levels of IL-beta, IL-6, TNF-alpha, I kappa B alpha, p50 and p65 through regulating TLR4/MyD88 pathway to rehabilitate inflammation. In addition, dioscin markedly up-regulated the expression levels of S1RT1, HO-1, NQO1, GST and GCLM through increasing nuclear translocation of Nr12 against oxidative stress. Furthermore, dioscin significantly decreased the expression levels of FasL, Fas, p53, Bak, Caspase-3/9, and upregulated Bcl-2 level through decreasing IRF9 level against apoptosis. In conclusion, dioscin showed protective effect against DMN-induced acute liver injury via ameliorating apoptosis, oxidative stress and inflammation, which should be developed as a new candidate for the treatment of acute liver injury in the future.

• 出版日期2016-7
• 单位大连医科大学