Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico

作者：Silva Zolezzi Irma; Hidalgo Miranda Alfredo; Estrada Gil Jesus; Carlos Fernandez Lopez Juan; Uribe Figueroa Laura; Contreras Alejandra; Balam Ortiz Eros; del Bosque Plata Laura; Velazquez Fernandez David; Lara Cesar; Goya Rodrigo; Hernandez Lemus Enrique; Davila Carlos; Barrientos Eduardo; March Santiago; Jimenez Sanchez Gerardo^*

来源：Proceedings of the National Academy of Sciences, 2009, 106(21): 8611-8616.

DOI：10.1073/pnas.0903045106

• admixture
• genetic variation
• population genetics
• SNP tagging

Mexico is developing the basis for genomic medicine to improve healthcare of its population. The extensive study of genetic diversity and linkage disequilibrium structure of different populations has made it possible to develop tagging and imputation strategies to comprehensively analyze common genetic variation in association studies of complex diseases. We assessed the benefit of a Mexican haplotype map to improve identification of genes related to common diseases in the Mexican population. We evaluated genetic diversity, linkage disequilibrium patterns, and extent of haplotype sharing using genomewide data from Mexican Mestizos from regions with different histories of admixture and particular population dynamics. Ancestry was evaluated by including 1 Mexican Amerindian group and data from the HapMap. Our results provide evidence of genetic differences between Mexican subpopulations that should be considered in the design and analysis of association studies of complex diseases. In addition, these results support the notion that a haplotype map of the Mexican Mestizo population can reduce the number of tag SNPs required to characterize common genetic variation in this population. This is one of the first genomewide genotyping efforts of a recently admixed population in Latin America.

• 出版日期2009-5-26