VHL: Cullin-g the Hypoxic Response

作者：Kershaw Nadia J; Babon Jeffrey J^*

来源：Structure, 2015, 23(3): 435-436.

DOI：10.1016/j.str.2015.02.003

Hypoxia inducible factor (HIF)-mediated response to hypoxic conditions is turned off by VHL-mediated ubiquitination of HIF alpha. To achieve this, VHL binds HIF alpha and recruits it to a specific E3 ubiquitin ligase complex, a Cullin-RING-ligase. In this issue of Structure, Nguyen et al. provide a structural view of how VHL engages the ligase in order to inhibit the hypoxic response.

• 出版日期2015-3-3
• 单位河北医科大学