ASYMMETRIC BIS(BIDENTATE) AZINE LIGAND AND TRANSITION METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA-BINDING AND CLEAVAGE STUDIES AND EXTRACTION PROPERTIES FOR SELECTED METALS AND DICHROMATE ANIONS

作者：Kulaksizoglu Sultan^*; Gokce Cansu; Gup Ramazan

来源：Journal of the Chilean Chemical Society, 2012, 57(3): 1213-1218.

• azine complexes
• DNA-interaction
• extraction
• heavy metals
• dichromate anions

New bis(bidentate) azine NNN'N' donor ligand was prepared by linking (1Z,1'Z)-1,1'-vertical bar propane-1,3-diylbis[oxybenzene-4,1-diy1(1Z)eth-1-yl-1-ylidene]] dihydra-zinc to pyridine-2-carbaldehyde. Two kinds of copper(II) and nickel(11) complexes with different stoichiometries were prepared. Reaction of bis(azine) ligand with Cu(II) and Ni(I I) chloride with 1:1 molar ratio gave azine complexes with stoichiometry [M(L)Cl-2] while 2:1 molar ratio reaction of Cu( II) and Ni(11) chloride with bis(azine) composed binuclear copper complexes with general stoichiometry [M-2(L)Cl-4]. The structures of both his-azine ligand and its complexes were identified by elemental analysis, infrared spectra. UV-Vis electronic absorption spectra and magnetic susceptibility measurements, TGA and powder XRD. DNA binding and DNA cleavage activities of the synthesized metal complexes were examined by using CV-vis titration and agarose gel electrophoresis, respectively. The results indicate that all the complexes bind significantly calf thymus DNA and cleavage pBR322 DNA. Furthermore, the complexing properties of the his-twine ligand toward selected transition metal cations and dichromate anions were also reported.

• 出版日期2012-9