Notable Pink Excreta and Severe Myocardial Suppression in Superwarfarin (difethialone) Intoxication

作者：Kamijo Yoshito^*; Sato Chie; Yoshimura Kuniko; Soma Kazui

来源：Internal Medicine, 2011, 50(22): 2819-2822.

DOI：10.2169/internalmedicine.50.5881

• difethialone
• superwarfarin
• red-dyed pellet
• pink-colored excreta
• myocardial suppression
• percutaneous cardiopulmonary support (PCPS)

Patients rarely consult physicians before developing coagulopathy or bleeding in most reported cases of superwarfarin intoxication. A 57-year-old woman ingested red-dyed pellets of anticoagulant rodenticide containing difethialone and warfarin as well as tablets of nitrazepam. Although she presented to the hospital in a comatose state, notable pink-colored excreta hinted at the consumption of anticoagulant rodenticide, which led to the early diagnosis of superwarfarin intoxication. Supplementation of large doses of intravenous and oral vitamin K successfully prevented coagulopathy and bleeding. On the other hand, temporary and reversible myocardial suppression was extremely severe, and required the introduction of percutaneous cardiopulmonary support.

• 出版日期2011