A highly efficient synthesis of 1,2,3,4-tetrahydroquinolines by molecular iodine-catalyzed domino reaction of anilines with cyclic enol ethers

作者：Lin Xu Feng; Cui Sun Liang; Wang Yan Guang^*

来源：Tetrahedron Letters, 2006, 47(26): 4509-4512.

DOI：10.1016/j.tetlet.2006.03.123

A highly efficient method for the synthesis of 1,2,3,4-tetrahydroquinoline derivatives via a molecular iodine catalyzed domino reaction of anilines with cyclic enol ethers, such as 2,3-dihydrofuran and 3,4-dihydro-2H-pyran. is described. The reaction may proceed through an aza-Diels-Alder process between an in situ generated 2-azadiene and another equivalent of cyclic enol.

• 出版日期2006-6-26
• 单位浙江大学